vcflib

Install command:
brew install vcflib

C++ library and cmdline tools for parsing and manipulating VCF files

https://github.com/vcflib/vcflib

License: MIT

Development: Pull requests

Formula JSON API: /api/formula/vcflib.json

Formula code: vcflib.rb on GitHub

Bottle (binary package) installation support provided for:

macOS on
Apple Silicon
golden gate
tahoe
sequoia
sonoma
macOS on
Intel
sonoma
Linux ARM64
x86_64

Current versions:

stable 1.0.15

Depends on:

htslib 1.24 C library for high-throughput sequencing data formats
wfa2-lib 2.3.6 Wavefront alignment algorithm library v2
xz 5.8.4 General-purpose data compression with high compression ratio
libomp 23.1.1 LLVM's OpenMP runtime library

Depends on when building from source:

cmake 4.4.3 Cross-platform make
pkgconf 3.0.7 Package compiler and linker metadata toolkit
pybind11 3.1.0 Seamless operability between C++11 and Python
python@3.14 3.14.7 Interpreted, interactive, object-oriented programming language

Uses from macOS: bzip2

Binaries: abba-baba, bFst, bed2region, bgziptabix, dumpContigsFromHeader, genotypeSummary, hapLrt, iHS, meltEHH, normalize-iHS, pFst, pVst, permuteGPAT++, permuteSmooth, plotHaps, popStats, segmentFst, segmentIhs, sequenceDiversity, smoother, vcf2bed.py, vcf2dag, vcf2fasta, vcf2sqlite.py, vcf2tsv, vcf_strip_extra_headers, vcfaddinfo, vcfafpath, vcfallelicprimitives, vcfaltcount, vcfannotate, vcfannotategenotypes, vcfbiallelic, vcfbreakmulti, vcfcat, vcfcheck, vcfclassify, vcfcleancomplex, vcfclearid, vcfclearinfo, vcfcombine, vcfcommonsamples, vcfcomplex, vcfcountalleles, vcfcreatemulti, vcfdistance, vcfecho, vcfentropy, vcfevenregions, vcffilter, vcffirstheader, vcffixup, vcfflatten, vcfgeno2alleles, vcfgeno2haplo, vcfgenosamplenames, vcfgenosummarize, vcfgenotypecompare, vcfgenotypes, vcfglbound, vcfglxgt, vcfgtcompare.sh, vcfhetcount, vcfhethomratio, vcfindelproximity, vcfindels, vcfindex, vcfinfo2qual, vcfinfosummarize, vcfintersect, vcfjoincalls, vcfkeepgeno, vcfkeepinfo, vcfkeepsamples, vcfld, vcfleftalign, vcflength, vcfmultiallelic, vcfmultiway, vcfmultiwayscripts, vcfnobiallelicsnps, vcfnoindels, vcfnosnps, vcfnulldotslashdot, vcfnullgenofields, vcfnumalt, vcfoverlay, vcfparsealts, vcfplotaltdiscrepancy.r, vcfplotaltdiscrepancy.sh, vcfplotsitediscrepancy.r, vcfplottstv.sh, vcfprimers, vcfprintaltdiscrepancy.r, vcfprintaltdiscrepancy.sh, vcfqual2info, vcfqualfilter, vcfrandom, vcfrandomsample, vcfregionreduce, vcfregionreduce_and_cut, vcfregionreduce_pipe, vcfregionreduce_uncompressed, vcfremap, vcfremoveaberrantgenotypes, vcfremovenonATGC, vcfremovesamples, vcfroc, vcfsample2info, vcfsamplediff, vcfsamplenames, vcfsitesummarize, vcfsnps, vcfsort, vcfstats, vcfstreamsort, vcfuniq, vcfuniqalleles, vcfvarstats, vcfwave, wcFst

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